Thomas Jefferson, in a letter to John Adams, (after both had left office), 1816

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"The answer" to life, the universe & everything isn't 42 (Sorry, Douglas Adams), but the fine structure constant, α (alpha), equal to the proportional strength of the electromagnetic interaction between elementary charged particles:

α = ⁠e²4πε₀ħc ⁠≅ 1/137.0